Methioninsulfoximid

Andre navne: Methioninsulfoximin; 2-amino-4-(Smethylsulfonimidosyl)butansyre; L-S-(3-amino-3-carboxypropyl)-S-methylsulfoximin. (Eng.: Methionine sulfoximine)

Methioninsulfoximid er et derivat af aminosyren methionin. Methioninsulfoximid er fundet i brød bagt af mel der er behandlet med melblegningsmidlet nitrogentrichlorid. Methioninsulfoximid og dens analoger hæmmer enzymet glutaminsyntetase hvorved syntesen af aminosyren glutamin forstyrres, da glutamin er en neurotransmitter kan det forklare hvorfor methioninsulfoximid kan inducere kramper (Griffith and Meister 1978).

MV= 180,23 g/mol; SMP> 210^oC (dec.); bruttoformel: C₅H₁₂N₂O₃S; CAS-nummer: 15985-39-4 (L-formen)

K73, Challenger, F. 1953. The biological importance of organic compounds of sulphur. Endeavour. 12:173-181 (E576); Griffith, O.W. and Meister, A. 1978. Differential inhibition of glutamine and γ-glutamylcysteine synthetases by α-alkyl analogs of methionine sulfoximine that induce convulsions. The Journal of Biological Chemistry. 253:2333-2338 (6832); (6833)

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